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Yong Xue joined the J. Craig Venter Institute in Rockville, MD in 2018 in the Synthetic Biology and Bioenergy Group. His research interests involve expanding TAR cloning synthetic genomics tools, developed by Dr. Sanjay Vashee, to various viruses to facilitate vaccines development. He was also involved in developing broad range applications of synthetic microbiomes.
Prior to joining JCVI, Dr. Xue was an ORISE fellow at U.S. Food and Drug Administration where he worked on development of flow cytometric based rapid detection and enumeration platform of food-borne pathogens (RAPID-B). Dr. Xue holds a bachelor’s degree in microbiology from the Shandong University, a master’s degree in molecular microbiology from Virginia Tech, and a Ph.D. degree in molecular genetics from University of Arkansas at Little Rock.
Research Priorities
Signature infiltration and maintenance on plasmid elements creating a forensic microbial system
- Design unique barcoded signatures and develop loop-mediated amplification (LAMP) and qPCR methods for rapid detection of signatures in field.
Elucidation of functions and genetic networks of HSV-1 virion proteins
- Assemble HSV-1 genomes from part fragments with desired mutations.
- Analyze protein interactions of HSV-1 virion proteins by GFP-trap, Western, and MS.
Generation and characterization of the SARS-CoV-2 infectious virus to facilitate therapeutic and vaccine development
- Deconstruct SARS-CoV-2 genome and reassemble infectious clones with reporter genes.
- Development of mouse adapted SARS-CoV-2 strains for in vivo studies.
Publications
Research Priorities
Signature infiltration and maintenance on plasmid elements creating a forensic microbial system
- Design unique barcoded signatures and develop loop-mediated amplification (LAMP) and qPCR methods for rapid detection of signatures in field.
Elucidation of functions and genetic networks of HSV-1 virion proteins
- Assemble HSV-1 genomes from part fragments with desired mutations.
- Analyze protein interactions of HSV-1 virion proteins by GFP-trap, Western, and MS.
Generation and characterization of the SARS-CoV-2 infectious virus to facilitate therapeutic and vaccine development
- Deconstruct SARS-CoV-2 genome and reassemble infectious clones with reporter genes.
- Development of mouse adapted SARS-CoV-2 strains for in vivo studies.