Bryan C. Frank, MSc, MBA, PMP

Scientific Project Manager
301-795-7806

Bryan Frank is a scientific project manager in the Infectious Disease Group. He has been involved in a wide array of genomic and infectious disease-based studies dating back to his start at The Institute for Genomic Research in 2001 working on mammalian models of human diseases. He developed high-throughput real-time quantitative RT-PCR and microarray protocols for the Institute running the TIGR Microarray Core Facility for its duration.

He has worked on a number or projects at JCVI related to persister states of Burkholderia, urine catheter biofilm and stool sample carbepenem resistance, multivalent vaccines for influenza, deep-sea soil core samplings, uranium mill tailings, as well as hypertension, pulmonary inflammation, autism, and other mammalian systemic conditions.

Bryan received his PMP (2017) from the Project Management Institute and his M.Sc. and MBA (2006) from Johns Hopkins University.

Research Priorities

Studying host-pathogen interactions to elucidate gene networks critical to the infection pathway and for the host response
  • The role of B. pseudomallei persisters in meliodosis drug resistance and reemergence
  • S. aureus strain differences from a genomic and transcriptomic perspective in acquired resistant infections.
Antimicrobial resistance in the human microbiome and its correlation to disease manifestation.
  • Analysis of carbapenem resistance with indwelling urinary catheter biofilms
  • Exploring the existence of innate presence of antimicrobial resistance in fecal samples before and after malarial treatments
Development of robust and rapid detection methods for use in biosurveillance of environmentally complex communities.
  • Analysis of diverse aeronautical samples testing for incidental human microbiome transmission
  • Screening of variable aeronautical locations probing for the presence of fungal pathogens

Publications

Rajagopala SV, Singh H, Yu Y, Zabokrtsky KB, Torralba MG, Moncera KJ, Frank B, Pieper R, Sender L, Nelson KE
Persistent Gut Microbial Dysbiosis in Children with Acute Lymphoblastic Leukemia (ALL) During Chemotherapy.
Microbial ecology. 2020-05-01; 79.4: 1034-1043.
PMID: 31754744
Brinkac L, Clarke TH, Singh H, Greco C, Gomez A, Torralba MG, Frank B, Nelson KE
Spatial and Environmental Variation of the Human Hair Microbiota.
Scientific reports. 2018-06-13; 8.1: 9017.
PMID: 29899411
Jones MB, Nierman WC, Shan Y, Frank BC, Spoering A, Ling L, Peoples A, Zullo A, Lewis K, Nelson KE
Reducing the Bottleneck in Discovery of Novel Antibiotics.
Microbial ecology. 2017-04-01; 73.3: 658-667.
PMID: 27896376
Tarabichi Y, Li K, Hu S, Nguyen C, Wang X, Elashoff D, Saira K, Frank B, Bihan M, Ghedin E, Methé BA, Deng JC
The administration of intranasal live attenuated influenza vaccine induces changes in the nasal microbiota and nasal epithelium gene expression profiles.
Microbiome. 2015-12-15; 3.74.
PMID: 26667497
Jones MB, Montgomery CP, Boyle-Vavra S, Shatzkes K, Maybank R, Frank BC, Peterson SN, Daum RS
Genomic and transcriptomic differences in community acquired methicillin resistant Staphylococcus aureus USA300 and USA400 strains.
BMC genomics. 2014-12-19; 15.1145.
PMID: 25527145
Ansong C, Schrimpe-Rutledge AC, Mitchell HD, Chauhan S, Jones MB, Kim YM, McAteer K, Deatherage Kaiser BL, Dubois JL, Brewer HM, Frank BC, McDermott JE, Metz TO, Peterson SN, Smith RD, Motin VL, Adkins JN
A multi-omic systems approach to elucidating Yersinia virulence mechanisms.
Molecular bioSystems. 2013-01-27; 9.1: 44-54.
PMID: 23147219
Deatherage Kaiser BL, Li J, Sanford JA, Kim YM, Kronewitter SR, Jones MB, Peterson CT, Peterson SN, Frank BC, Purvine SO, Brown JN, Metz TO, Smith RD, Heffron F, Adkins JN
A Multi-Omic View of Host-Pathogen-Commensal Interplay in Salmonella-Mediated Intestinal Infection.
PloS one. 2013-01-01; 8.6: e67155.
PMID: 23840608
Bordbar A, Mo ML, Nakayasu ES, Schrimpe-Rutledge AC, Kim YM, Metz TO, Jones MB, Frank BC, Smith RD, Peterson SN, Hyduke DR, Adkins JN, Palsson BO
Model-driven multi-omic data analysis elucidates metabolic immunomodulators of macrophage activation.
Molecular systems biology. 2012-06-26; 8.558.
PMID: 22735334
Sun F, Ji Q, Jones MB, Deng X, Liang H, Frank B, Telser J, Peterson SN, Bae T, He C
AirSR, a [2Fe-2S] cluster-containing two-component system, mediates global oxygen sensing and redox signaling in Staphylococcus aureus.
Journal of the American Chemical Society. 2012-01-11; 134.1: 305-14.
PMID: 22122613
Schrimpe-Rutledge AC, Jones MB, Chauhan S, Purvine SO, Sanford JA, Monroe ME, Brewer HM, Payne SH, Ansong C, Frank BC, Smith RD, Peterson SN, Motin VL, Adkins JN
Comparative omics-driven genome annotation refinement: application across Yersiniae.
PloS one. 2012-01-01; 7.3: e33903.
PMID: 22479471
House CD, Vaske CJ, Schwartz AM, Obias V, Frank B, Luu T, Sarvazyan N, Irby R, Strausberg RL, Hales TG, Stuart JM, Lee NH
Voltage-gated Na+ channel SCN5A is a key regulator of a gene transcriptional network that controls colon cancer invasion.
Cancer research. 2010-09-01; 70.17: 6957-67.
PMID: 20651255

Research Priorities

Studying host-pathogen interactions to elucidate gene networks critical to the infection pathway and for the host response
  • The role of B. pseudomallei persisters in meliodosis drug resistance and reemergence
  • S. aureus strain differences from a genomic and transcriptomic perspective in acquired resistant infections.
Antimicrobial resistance in the human microbiome and its correlation to disease manifestation.
  • Analysis of carbapenem resistance with indwelling urinary catheter biofilms
  • Exploring the existence of innate presence of antimicrobial resistance in fecal samples before and after malarial treatments
Development of robust and rapid detection methods for use in biosurveillance of environmentally complex communities.
  • Analysis of diverse aeronautical samples testing for incidental human microbiome transmission
  • Screening of variable aeronautical locations probing for the presence of fungal pathogens
17-May-2018
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